Article Text

Download PDFPDF

Subacute sclerosing panencephalitis
Free
  1. R K Garg
  1. Correspondence to:
 Dr Ravindra Kumar Garg, Department of Neurology, King George's Medical College, Lucknow 226 003, India;
 garg50{at}yahoo.com

Abstract

Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder of childhood and early adolescence. It is caused by persistent defective measles virus. Brain biopsies or postmortem histopathological examination show evidence of astrogliosis, neuronal loss, degeneration of dendrites, demyelination, neurofibrillary tangles, and infiltration of inflammatory cells. Patients usually have behavioral changes, myoclonus, dementia, visual disturbances, and pyramidal and extrapyramidal signs. The disease has a gradual progressive course leading to death within 1-3 years. The diagnosis is based upon characteristic clinical manifestations, the presence of characteristic periodic EEG discharges, and demonstration of raised antibody titre against measles in the plasma and cerebrospinal fluid. Treatment for SSPE is still undetermined. A combination of oral isoprinosine (Inosiplex) and intraventricular interferon alfa appears to be the best effective treatment. Patients responding to treatment need to receive it life long. Effective immunisation against measles is the only solution presently available to the problem of this dreaded disease.

  • measles
  • subacute sclerosing panencephalitis
  • slow virus infection interferon alfa, isoprinosine
  • EEG, electroencephalogram
  • ELISA, enzyme linked immunosorbent assay
  • MRI, magnetic resonance imaging
  • SSPE, subacute sclerosing panencephalitis
View Full Text

Statistics from Altmetric.com

Footnotes

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.