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Hyperkalaemic quadriparesis secondary to chronic diclofenac treatment
  1. P Patel,
  2. B Mandal,
  3. M W Greenway
  1. Department of Health Care of the Elderly, Glan Clwyd Hospital, Bodelwyddan, Rhyl, Denbighshire LL18 5UJ, UK
  1. Dr Patel


A 76 year old woman presented with a quadriparesis associated with hyperkalaemia. She had a 10 month history of treatment with oral diclofenac sodium. On admission she had hyperkalaemic metabolic acidosis with a normal anion gap and mild renal impairment. Her weakness resolved after withdrawal of diclofenac and medical correction of her hyperkalaemia. Non-steroidal anti-inflammatory drugs are known to cause hyperkalaemic acidosis and should be used with caution, especially in the presence of renal impairment.

  • hyperkalaemic paralysis
  • drug induced hyperkalaemia
  • diclofenac sodium

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