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Calcium-channel blockade can mask the diagnosis of Conn's syndrome
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  1. Morris J Brown,
  2. Ruth V Hopper
  1. Clinical Pharmacology Unit, University of Cambridge, Box 110 Addenbrookes Hospital, Cambridge CB2 2QQ, UK

    Abstract

    A 30-year-old woman presented with hypertension and hypokalaemia, and was found to have primary aldosteronism due to a Conn's adenoma, whose removal cured the hypertension. Before surgery, the characteristic biochemical changes which enabled the diagnosis were completely masked by administration of a calcium-channel blocker, amlodipine. It is likely that widespread use of this class of drugs contributes to under-diagnosis of Conn's syndrome as a curable cause of hypertension.

    • Conn's syndrome
    • aldosterone
    • calcium blockade
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