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High-dose intravenous gammaglobulin therapy for acquired von Willebrand disease.
  1. P. J. Van Genderen,
  2. D. N. Papatsonis,
  3. J. J. Michiels,
  4. J. J. Wielenga,
  5. J. Stibbe,
  6. F. J. Huikeshoven
  1. Department of Haematology, University Hospital Dijkzigt, Rotterdam, The Netherlands.


    Patients with acquired von Willebrand disease may present with severe bleeding, which is usually difficult to manage. Adequate haemostasis in acquired von Willebrand disease may be achieved with the infusion of factor VIII/von Willebrand factor concentrates or with the administration of desmopressin. We report a case of acquired von Willebrand disease with severe postoperative bleeding, responding poorly to classical von Willebrand factor replacement therapy but successfully treated with high-dose intravenous gammaglobulins. This new treatment mode of acquired von Willebrand disease is discussed in the light of a critical analysis of the literature.

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