Article Text

Download PDFPDF

Dexamethasone-suppressible feminizing adrenal adenoma.
  1. M. Paja,
  2. S. Díez,
  3. T. Lucas,
  4. A. Ojeda,
  5. L. Salto,
  6. J. Estrada
  1. Servicio de Endocrinologia, Clínica Puerta de Hierro, C/San Martín de Porres 4, Madrid, Spain.


    A 39 year old man presented with gynaecomastia, loss of libido and high blood pressure. Hormone studies revealed elevated plasma levels of oestradiol and its precursors, which increased in response to adrenocorticotrophic hormone and were reduced to normal levels with dexamethasone. Computed tomography disclosed a left adrenal mass and surgery was performed. The removed tumour weighed 84 g and the histological diagnosis was of adenoma. Nine years after surgery, he is asymptomatic, without hypertension, and radiological and or hormonal evidence of recurrence. We discuss the hormone profile in this case and the dynamics of steroid production by the tumour which, in contrast to the classical concept of tumour autonomy, showed dependence of oestradiol secretion on endogenous adrenocorticotrophic hormone.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.