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The Jarisch-Herxheimer reaction in leptospirosis.
  1. C. Vaughan,
  2. C. C. Cronin,
  3. E. K. Walsh,
  4. M. Whelton
  1. Cork Regional Hospital, Department of Medicine, Wilton, Ireland.


    Three patients with leptospirosis whose condition worsened after initiation of antibiotic therapy are reported. Their clinical deterioration appeared to be due to the development of the Jarisch-Herxheimer reaction rather than to progression of their underlying infection. Relevant aspects of the management of patients with leptospirosis are discussed.

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