Article Text


Type IV renal tubular acidosis and spironolactone therapy in the elderly.
  1. J. E. O'Connell,
  2. N. R. Colledge
  1. Geriatric Medicine Unit, University of Edinburgh, City Hospital, UK.


    Spironolactone therapy is a well-known cause of hyperkalaemia, but in susceptible patient, it may also be associated with metabolic acidosis. We report a case of severe renal tubular acidosis (Type IV) with life-threatening hyperkalaemia caused by spironolactone, and discuss the mechanisms by which this may occur.

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