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First use of G-CSF in chlorpromazine-induced agranulocytosis: a report of two cases.
  1. J. R. Kendra,
  2. F. P. Rugman,
  3. T. A. Flaherty,
  4. A. Myers,
  5. N. Horsfield,
  6. A. Barton,
  7. L. Russell
  1. Burnley General Hospital, UK.


    Chlorpromazine-induced agranulocytosis is an uncommon disorder associated with a high frequency of fatality. We describe two patients with chlorpromazine-induced granulocytosis in whom granulocyte colony stimulating factor (G-CSF) administration enhanced the speed of neutrophil recovery. No toxicity was noted with G-CSF and both patients made a successful recovery. We propose there is a role for such cytokine therapy in patients with life-threatening agranulocytosis in order to speed the recovery of neutrophils.

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