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Solitary plasmacytoma of bone--a rare disorder with an unusual evolution.
  1. R. K. Ganjoo,
  2. J. S. Malpas,
  3. P. N. Plowman
  1. Imperial Cancer Research Fund Department of Medical Oncology, St Bartholomew's Hospital, West Smithfield, London, UK.


    A 40 year old woman presented with a spinal epidural tumour, which on histology was shown to be a plasmacytoma. At that time she had no evidence of multiple myeloma. Ten months later, she developed a second isolated plasmacytoma in the spleen, for which she underwent splenectomy. Two years after her initial presentation she had another recurrence in the liver, followed by a full-blown picture of multiple myeloma. The myeloma was progressive and resistant to all forms of chemotherapy. She finally died of a massive gastrointestinal haemorrhage. The clinical features, natural evolution and management of solitary plasmacytomas are discussed.

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