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Brucellosis with nephrotic syndrome, nephritis and IgA nephropathy.
  1. N. Siegelmann,
  2. A. S. Abraham,
  3. B. Rudensky,
  4. O. Shemesh
  1. Department of Internal Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.


    A patient with systemic brucellosis due to Brucella melitensis had severe renal involvement. Clinical features included hypertension, macroscopic haematuria, massive proteinuria of 10 g per 24 hours and azotaemia. Following treatment with antibiotics, the azotaemia resolved and proteinuria decreased to less than 0.5 g per 24 hours, but microscopic haematuria and hypertension persisted. Renal biopsy during recovery revealed IgA nephropathy with minimal mesangial changes, suggesting a causal relation between brucellosis and IgA nephropathy with a reversible nephrotic syndrome.

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