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In situ demonstration of Epstein-Barr virus in intravenous drug abusers with generalized lymphadenopathy.
  1. F. Mampaso,
  2. C. Bellas,
  3. A. Molina,
  4. C. Quereda,
  5. T. Bricio,
  6. L. Buzon
  1. Department of Pathology, Hospital Ramon y Cajal, Madrid, Spain.


    We have studied by the in situ hybridization method the presence of Epstein-Barr virus (EBV) DNA genome in lymph node tissues from 11 patients with persistent generalized lymphadenopathy. Using a biotinylated EBV DNA probe, we demonstrated EBV nucleic acid in scattered germinal centre cells in eight of the 11 cases. Our results suggest that EBV is not a determinant factor in the pathogenesis of this lymphadenopathy, but support its possible implication in B cell malignant transformation in cases of AIDS-associated lymphoma.

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