Article Text


A preliminary study of the ocular hypotensive effects of bromocriptine in diabetic patients with autonomic neuropathy.
  1. M. R. al-Sereiti,
  2. P. Turner,
  3. E. A. Gale
  1. Department of Clinical Pharmacology, St Bartholomew's Hospital, London, UK.


    The effect of bromocriptine on intraocular pressure has been investigated in a group of 8 diabetic patients with autonomic neuropathy, to test the hypothesis that bromocriptine exerts its ocular hypotensive action through presynaptic dopamine receptors. Bromocriptine eye drops (0.025%) produced a significant fall in intraocular pressure in a control group of 8 matched normal volunteers, but this effect was not seen in the eyes of the diabetic patients. These results are consistent with a presynaptic site of action of bromocriptine.

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