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Histiocytic cytophagic panniculitis.
  1. D. A. Hilton,
  2. B. P. O'Malley,
  3. S. T. Durrant
  1. Department of Histopathology, Leicester Royal Infirmary, Infirmary Square, UK.


    A 33 year old man developed fever, malaise, jaundice, pancytopenia, coagulation abnormalities, hepatomegaly, pleural effusions and a subcutaneous lump. Biopsies revealed a lobular panniculitis with the presence of cytophagic histiocytes; erythrophagocytosis was also demonstrated in the liver and bone marrow. Despite the use of chemotherapy (CHOP) his clinical condition deteriorated and he died 5 months after presentation. This illness is consistent with the recently described syndrome of histiocytic cytophagic panniculitis.

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