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Intravenous infusions of ifosfamide/mesna and perturbation of warfarin anticoagulant control.
  1. G. Hall,
  2. M. J. Lind,
  3. M. Huang,
  4. A. Moore,
  5. A. Gane,
  6. J. T. Roberts,
  7. B. M. Cantwell
  1. University Department of Clinical Oncology, Newcastle General Hospital, Newcastle upon Tyne, UK.


    We report three patients who had serious disturbance of anticoagulant control while receiving ifosfamide/mesna-containing cytotoxic chemotherapy in association with warfarin. In view of the likely biological potentiation of warfarin by ifosfamide/mesna, close monitoring of anticoagulant control should be performed during the co-administration of these drugs.

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