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Type I protein S deficiency and skin necrosis.
  1. A. Craig,
  2. D. A. Taberner,
  3. A. H. Fisher,
  4. D. N. Foster,
  5. J. Mitra
  1. Department of Haematology, Withington Hospital, Manchester, UK.


    A kindred with Type I protein S deficiency is described in which the index case developed skin necrosis during induction of oral anticoagulant therapy for deep venous thrombosis. Two other family members with protein S deficiency have been detected, and demonstrate the clinical variability of this condition.

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