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Premature coronary artery disease and the Prader-Willi syndrome.
  1. S. R. Page,
  2. S. S. Nussey,
  3. G. A. Haywood,
  4. J. S. Jenkins
  1. Department of Medicine, St George's Hospital Medical School, London, UK.


    A 28 year old woman with the Prader-Willi syndrome developed chest pain and loss of anterior R wave amplitude on the electrocardiogram. Cardiac catheterization demonstrated a severe proximal stenosis of the left anterior descending artery with delayed antegrade flow together with antero-apical akinesia consistent with myocardial infarction. Physicians involved in the management of patients with the Prader-Willi syndrome should be aware of this association with premature coronary artery disease.

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