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Immobilization hypercalcaemia responding to intravenous pamidronate sodium therapy.
  1. H. D. McIntyre,
  2. D. P. Cameron,
  3. S. M. Urquhart,
  4. W. E. Davies
  1. Department of Endocrinology, Princess Alexandra Hospital, Brisbane, Australia.


    A 16 year old male developed symptomatic hypercalcaemia of immobilization on day 47 following a diving accident which had resulted in incomplete C4 tetraplegia. Following initial reduction in serum calcium with salmon calcitonin 100 U/day, symptomatic hypercalcaemia recurred. A single dose of 30 mg pamidronate sodium, given intravenously, caused serum calcium to fall within 48 hours. Initial mild, asymptomatic hypocalcaemia was followed by a return to sustained normocalcaemia. No major adverse reaction was encountered, and if further clinical experience confirms its efficacy, pamidronate sodium will warrant consideration as first-line therapy for immobilization hypercalcaemia.

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