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Beta-blockers, lipoproteins and non-insulin dependent diabetes.
  1. M. D. Feher,
  2. S. G. Rains,
  3. W. Richmond,
  4. D. Torrens,
  5. G. Wilson,
  6. J. Wadsworth,
  7. P. S. Sever,
  8. R. S. Elkeles
  1. Department of Clinical Pharmacology, St. Mary's Hospital, London, UK.


    In a study on 138 hypertensive non-insulin dependent diabetic subjects, factors influencing lipoproteins were assessed. Multiple regression analyses were carried out in order to assess the influence of beta-blocker antihypertensive therapy while making allowances for other confounding variables. In males, but not in females, on a beta-blocker for hypertension, total high density lipoprotein- (HDL-) and HDL-subfraction cholesterol were significantly lower while the serum triglyceride was increased, though not significantly. In male non-insulin dependent diabetics, regimens containing a beta-blocker may worsen an already abnormal lipoprotein profile and antihypertensive agents other than beta-blocking agents should be used if possible.

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