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Fatal Stevens-Johnson syndrome following urography with iopamidol in systemic lupus erythematosus.
  1. J. S. Savill,
  2. R. Barrie,
  3. S. Ghosh,
  4. M. Muhlemann,
  5. P. Dawson,
  6. C. D. Pusey
  1. Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.


    A 46 year old white woman with active systemic lupus erythematosus developed a skin rash 8 hours after intravenous urography with the non-ionic contrast medium iopamidol. Severe Stevens-Johnson syndrome with erythema multiforme, intrahepatic cholestasis, pulmonary infiltrates and acute renal failure ensued, leading to her death. Although non-ionic contrast media are generally less toxic than traditional ionic agents, their use in patients with immunological disease may be hazardous.

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