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Failure of penicillin prophylaxis in laboratory acquired leptospirosis.
  1. C. F. Gilks,
  2. H. P. Lambert,
  3. E. S. Broughton,
  4. C. C. Baker
  1. St. George's Hospital, London, UK.


    A laboratory technician developed leptospirosis following accidental inoculation, despite prompt administration of parenteral penicillin by an accepted regimen of post-exposure prophylaxis. Another technician was similarly exposed and was given doxycycline; no illness or serological conversion followed. The implications of these cases are discussed and recommendations made for post-exposure chemoprophylaxis with doxycycline.

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