Article Text


Is serodiagnosis of herpes simplex encephalitis safe?
  1. J. G. Coghlan,
  2. C. Monaghan,
  3. P. A. Carney,
  4. J. H. Moran
  1. Department of Neurology, Regional Hospital, Galway, Irish Republic.


    We present a case of probable tuberculous meningitis in which serological changes 'diagnostic' of herpes simplex encephalitis were found. Evidence is provided that the serological changes in this case represent a true false positive, and that reliance on clinical plus serological criteria to diagnose herpes simplex encephalitis could result in failure to diagnose and treat tuberculous meningitis.

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