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Acute polyarthritis following the use of Corynebacterium parvum vaccine (Coparvax) for malignant pleural effusion.
  1. A. M. Lever,
  2. J. Forsythe,
  3. P. Oxford


    A 77-year-old man with a malignant pleural effusion was treated by aspiration of fluid and injection of Corynebacterium parvum vaccine for pleurodesis. Within 24 hr he had developed a temperature and a neutropenia followed by an acute crippling polyarthritis of his hands and wrists which subsequently responded to oral steroids and non-steroidal antiinflammatory drugs.

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