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The need for prophylactic treatment to the central nervous system in patients with aggressive non-Hodgkin's lymphoma.
  1. C. J. Hawkey,
  2. P. J. Toghill


    During 2 years, 6 out of 34 patients presenting with newly diagnosed non-Hodgkin's lymphoma developed central nervous system (CNS) complications. All were male and had diffuse, undifferentiated lymphomas. In all 6 patients, CNS disease developed during, or shortly after, treatment. We suggest that a group at high risk from these complications can be identified and should be considered for a trial of prophylaxis.

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