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Failure of naloxone to reverse the cardiotoxocity of Distalgesic overdose
  1. C. J. Barraclough,
  2. R. A. Lowe


    A case of severe poisoning with dextropropoxyphene and paracetamol (Distalgesic) in which the cardiotoxic effects of dextropropoxyphene were not reversed by naloxone is reported. A probable reason for this failure is suggested with reference to the differing pharmacological actions of dextropropoxyphene on cardiac conducting tissue and the central nervous system.

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