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Early onset life-threatening myelosuppression after low dose of intravesical thiotepa
  1. Giancarlo Agnelli,
  2. Paolo Gresele,
  3. Maria de Cunto,
  4. Albano del Favero


    Intravesical instillation of thiotepa is a popular treatment for localized bladder carcinoma. The drug can enter the systemic circulation, and such absorption may be enhanced by extensive tumour infiltration or by a recent tumour resection. A case is reported of early onset life-threatening pancytopenia following an unusually low dose of the drug in a patient who had undergone a recent tumour resection.

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