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Jaundice associated with naproxen.
  1. R. M. Victorino,
  2. J. C. Silveira,
  3. A. Baptista,
  4. M. C. de Moura


    Hepatic injury in association with naproxen therapy is described and documented by liver biopsy in one patient. Histological findings were consistent with a drug-induced hepatitis, and cessation of therapy led to reversal of the clinical and biochemical changes. Circumstantial evidence is in favour of a hypersensitivity response to the drug rather than direct hepatotoxicity. Increased awareness of clinicians of this probably rare side effect of naproxen may help prompt identification of similar cases.

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