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A review of the Zollinger-Ellison syndrome--with particular reference to a patient treated with cimetidine.
  1. R. J. Wyke,
  2. G. L. Hill,
  3. A. T. Axon


    A case of the Zollinger-Ellison syndrome, presented with watery diarrhoea, malabsorption and multiple duodenal ulcers. Resection of a gastrinoma from the head of the pancreas was ineffective. Cimetidine, administered for more than 30 months produced an immediate and sustained relief of symptoms with a gain in weight of 19 kg and improvement of the biochemical features of malabsorption. Gastric acid secretion has been markedly inhibited and duodenal ulceration healed.

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