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Cimetidine in the prevention of gastric ulcer relapse.
  1. R. J. Machell,
  2. P. J. Ciclitira,
  3. M. J. Farthing,
  4. A. P. Dick,
  5. J. O. Hunter


    Twenty-five patients with healed gastric ulcers completed an 11-month double-blind controlled trial comparing cimetidine 1 g daily with placebo in the prevention of ulcer relapse. Ulcers recurred in 14 patients, 12 on placebo, 2 on cimetidine. In 11 patients, 9 on cimetidine, 2 on placebo, the ulcers remained healed at the end of the trial (P less than 0.002). Cimetidine 1 g daily significantly reduces the relapse rate in gastric ulceration.

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