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Erythro-myeloid aplasia following D-penicillamine treatment in primary biliary cirrhosis
  1. S. Jones,
  2. R. E. T. Corringham,
  3. Stephan Jain


    A woman with primary biliary cirrhosis and a high liver copper concentration was treated with D-penicillamine as a participant in a controlled trial of the drug. After 14 weeks she developed a Pseudomonas septicaemia and was found to have erythro-myeloid aplasia. Similar, but not identical blood dyscrasias have previously been reported as complications of D-penicillamine therapy. She survived after treatment with antibiotics and granulocyte transfusions, and bone marrow function returned to normal.

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