The efficacy of intraperitoneal noxythiolin and povidone-iodine was compared in mice and rats with induced Gram-negative peritonitis. Noxythiolin 1% solution reduced the mortality of mice from 65 to 41% (P<0·1) but was ineffective in rats. Povidone-iodine (6·0-7·5 mg available iodine/kg body weight) significantly reduced the mortality of both mice (P<0·001) and rats (P<0.01) in treated animals compared to matched controls. The mortality rate of rats treated with povidone-iodine was significantly less than those treated with noxythiolin (P<0·01).
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