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Effect of prolonged therapy with neuroleptics on hepatic microsomal enzyme activity in schizophrenic patients
  1. Sisir K. Majumdar,
  2. Pravin P. Kakad


    Gamma-glutamyl transpeptidase (GGT) is one of the hepatic microsomal enzymes and is now considered to be a reliable biochemical marker of enzyme induction.

    Serum levels of this hepatic microsomal enzyme were estimated in twenty-eight schizophrenic patients treated with neuroleptics (fluphenazine, flupenthixol and chlorpromazine) for a prolonged period. No biochemical evidence of induction of the hepatic microsomal enzymes was noticed. It is suggested that these drugs may not cause hepatic microsomal enzyme induction in humans and that interference of rates of metabolism via enzyme induction in other drugs used concurrently need not be anticipated.

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