Article Text

Download PDFPDF

Preparation and properties of a novel influenza subunit vaccine
  1. H. Bachmayer,
  2. E. Liehl,
  3. G. Schmidt


    Haemagglutinin and neuraminidase have clearly been shown to be responsible for the stimulation of immunity against influenza.

    In the approach described, these two immunogens are selectively solubilized, leaving an intact subviral particle which contains lipid and non-protective components. The methods used can readily be adapted to large scale production.

    The immunogenicity of such antigen-preparation was studied in different animal species. Antibodies against haemagglutinin and neuraminidase were measured in mice, hamsters, guinea-pigs and rabbits. In addition, mice-protection experiments were performed.

    The immune response of volunteers to this type of subunit vaccine has also been evaluated (Kunz and Hofmann, 1975). Results of a first field trial indicate that the solubilization procedure did not alter the immunogenic properties of the two antigens.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.