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Diffuse vasculitis, eosinophilia, and elevated antibody titre to measles virus
  1. R. C. Bucknall,
  2. R. Doshi


    In the original description of serum sickness by Von Pirquet and Schick (1905) vasculitis was described as a feature. This was subsequently shown to be due to circulating immune complexes, which are known to be eosinotactic. The following report describes a case of serum sickness, occurring in a 14-year-old boy, characterized by diffuse vasculitis with communicating hydrocephalus and accompanied by a pronounced eosinophilia. A significantly raised antibody (IgG) titre to measles virus was demonstrated in his serum and indicated that this agent probably provided the initial antigenic stimulus.

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