A case of Spirillum endocarditis causing severe aortic regurgitation in a 26-year-old man is reported. The infection responded to treatment with oxytetracycline followed by ampicillin, but the valvular damage led to progressive left ventricular failure. The valve was replaced with a fresh nutrient homograft and the patient made a good recovery. A normal aortic valve appeared to have been infected.
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