Dogs challenged with toxic doses of methylsalicylate developed acute myocardiopathy. Metabolic manifestations of uncoupling of oxidative phosphorylation by methylsalicylate (MS) were observed. Oxygen consumption increased two-fold. The haemodynamic abnormalities produced by intervention were minimal. The measured metabolic parameters indicated profound derangement. A net efflux of orthophosphate, lactate and potassium was observed from the myocardium. Marked hyperkalaemia occurred terminally. Morphological changes were observed on electron microscopy.
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