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Primary biliary cirrhosis in brothers
  1. R. Bown,
  2. M. L. Clark,
  3. D. Doniach


    This is the first report of two brothers who demonstrated the classical clinical course, histology, biochemistry and auto-antibodies of primary biliary cirrhosis. Both also exhibited an associated keratoconjunctivitis sicca and, in one, renal tubular acidosis resulted in severe systemic acidosis after lactulose therapy and with a subsequent intraperitoneal variceal rupture.

    Screening of the relatives recalled a high incidence of ‘auto-immune’ disease and auto-antibodies.

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