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Neonatal hepatitis syndrome and alpha-1-antitrypsin deficiency: an epidemiological study in South-East England
  1. K. Cottrall,
  2. P. J. L. Cook,
  3. A. P. Mowat


    A prospective epidemiological study of the Neonatal Hepatitis Syndrome in S.E. England showed Alpha-1-Antitrypsin Deficiency (Pi ZZ) to be present in seven out of fifty-two patients. Data are considered from these seven patients, and from a further six cases from outside this area. The nature of acute illness, pathological changes on early liver biopsy, and short-term prognosis show considerable variability, but in general the hepatitis is more severe in patients with Alpha-1-A.T. deficiency than in those in whom no aetiological factor was found.

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