The results of a controlled experiment in which an attempt was made to transmit sarcoidosis by inoculation of sarcoid and non-sarcoid lymph node homogenates into the footpads of normal and immunologically deficient mice, are reported.
The early and late changes in the footpads were assessed microscopically. A substantial proportion of the footpads of mice receiving sarcoid homogenate showed the histological characteristics typical of sarcoidosis in man and evolved fully only after a period of 6-8 months following inoculation. Moreover, positive Kveim tests were confined to a proportion of those mice given sarcoid homogenates and were all associated with a sarcoid granuloma in the footpad.
Conversely, the inflammatory lesions seen in the early histology of the footpads of mice inoculated with non-sarcoid homogenate were no longer apparent in the late histology and Kveim tests in all mice given non-sarcoid homogenate were negative.
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