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An attempt to demonstrate a transmissible agent from sarcoid material
  1. D. N. Mitchell,
  2. R. J. W. Rees


    The results of a controlled experiment in which an attempt was made to transmit sarcoidosis by inoculation of sarcoid and non-sarcoid lymph node homogenates into the footpads of normal and immunologically deficient mice, are reported.

    The early and late changes in the footpads were assessed microscopically. A substantial proportion of the footpads of mice receiving sarcoid homogenate showed the histological characteristics typical of sarcoidosis in man and evolved fully only after a period of 6-8 months following inoculation. Moreover, positive Kveim tests were confined to a proportion of those mice given sarcoid homogenates and were all associated with a sarcoid granuloma in the footpad.

    Conversely, the inflammatory lesions seen in the early histology of the footpads of mice inoculated with non-sarcoid homogenate were no longer apparent in the late histology and Kveim tests in all mice given non-sarcoid homogenate were negative.

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    • * This paper has already appeared in the Lancet, (1969, ii, 81. D.N. Mitchell & R.J.W. Rees. A transmissible agent from sarcoid tissue) and is reproduced by kind permission of the Editor.

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