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Generalised lentiginosis and café noir spots leading to a diagnosis of LEOPARD syndrome
  1. Ankur Guliani1,
  2. Sheetanshu Kumar1,
  3. Dipankar De1,
  4. Divya Aggarwal2,
  5. Bishan Dass Radotra2
  1. 1 Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  2. 2 Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  1. Correspondence to Dr. Dipankar De, Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India; dr_dipankar_de{at}yahoo.in

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Dermatology consultation was sought for a 15-year-old boy with generalised lentiginosis since infancy (figure 1A). He also had darkly pigmented, irregular, larger lesions up to 2 cm in size suggestive of café noir spots1 (figure 1B).

Figure 1

(A) Multiple darkly pigmented macules all over the body suggestive of lentigines. (B) Well-defined, darkly pigmented, irregular patches, larger in size up to 2 cm suggestive of café noir spots.

Dermoscopy revealed pigment network, black dots and dark globules (figure 2A). He also had facial dysmorphism, low set ears, significant growth retardation and below average IQ of 82. Puberty was not attained yet in the patient …

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