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Wilson disease: more than meets the eye
  1. Claire Kelly1,2,
  2. Marinos Pericleous1,2
  1. 1Department of Gastroenterology and Hepatology, Royal Surrey County Hospital, Guildford, UK
  2. 2Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK
  1. Correspondence to Dr Claire Kelly, Department of gastroenterology and hepatology, Royal Surrey County Hospital, Guildford GU2 7XX, UK; clairekelly4{at}nhs.net

Abstract

Wilson disease is a rare but important disorder of copper metabolism, with a failure to excrete copper appropriately into bile. It is a multisystem condition with presentations across all branches of medicine. Diagnosis can be difficult and requires a high index of suspicion. It should be considered in unexplained liver disease particularly where neuropsychiatric features are also present. Treatments are available for all stages of disease. A particularly important presentation not to overlook is acute liver failure which carries a high mortality risk and may require urgent liver transplantation. Here, we provide an overview of this complex condition.

  • hepatology
  • movement disorder
  • copper metabolism

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Footnotes

  • Contributors Both authors were involved in the conceptualisation of the work and designed the manuscript. They have carried out the literature review and drafted the work and revised it critically for important intellectual content. They have also provided final approval of the version to be published and hereby agree to be accountable for the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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