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Crizotinib is a multitarget tyrosine kinase inhibitor used in treating non-small cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK) gene mutation. Common and well-known adverse effects include gastrointestinal disturbance, dizziness, fatigue, liver enzyme elevation and visual disturbance. We describe here a patient with NSCLC who presented with symptomatic bradycardia due to crizotinib.
The patient was a 69-year-old Chinese male with stage IV epidermal growth factor receptor-negative, ALK-rearranged NSCLC. He presented to the emergency department complaining of breathlessness, swollen legs and hiccups. He had type 2 diabetes mellitus but no previous cardiovascular disease. He was taking crizotinib 250 mg twice daily, vildagliptin …
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