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Cardiac manifestations in alcoholic liver disease
  1. Sandra Milić1,
  2. Davorka Lulić2,
  3. Davor Štimac1,
  4. Alen Ružić2,
  5. Luka Zaputović2
  1. 1Department of Gastroenterology, Internal Medicine Clinic, University Hospital Rijeka, Rijeka, Croatia
  2. 2Department of Cardiovascular Disease, Internal Medicine Clinic, University Hospital Rijeka, Rijeka, Croatia
  1. Correspondence to Professor Sandra Milić, Department of Gastroenterology, Internal Medicine Clinic, University Hospital Rijeka, Krešimirova 42, Rijeka 51000, Croatia; smilic05{at}gmail.com

Abstract

Alcoholic liver disease is the most prevalent cause of progressive liver disease in Europe. Alcoholic cirrhosis occurs in 8%–20% of cases of alcoholic liver disease. It has significant influence on cardiovascular system and haemodynamics through increased heart rate, cardiac output, decreased systemic vascular resistance, arterial pressure and plasma volume expansion. Cirrhotic cardiomyopathy is characterised by systolic and diastolic dysfunction and electrophysiological abnormalities, if no other underlying cardiac disease is present. It is often unmasked only during pharmacological or physiological stress, when compensatory mechanisms of the heart become insufficient to maintain adequate cardiac output. Low-to-moderate intake of alcohol can be cardioprotective. However, heavy drinking is associated with an increased risk of cardiovascular diseases, such as alcoholic cardiomyopathy, arterial hypertension, atrial arrhythmias as well as haemorrhagic and ischaemic stroke. Alcoholic cardiomyopathy is characterised by dilated left ventricle (LV), increased LV mass, normal or reduced LV wall thickness and systolic dysfunction.

  • Alcoholic liver disease
  • Alcoholic liver cirrhosis
  • Cirrhotic cardiomyopathy
  • Hemodynamics
  • Alcoholic cardiomyopathy

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