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Effect of short-term positive airway pressure on blood pressure in controlled hypertensive patients with obstructive sleep apnoea syndrome: a prospective cohort study
  1. José Heriston de Morais Lima1,2,
  2. Amilton da Cruz Santos1,2,
  3. Sandra Emília Benício Barros2,3,
  4. Pollyana Soares de Abreu Morais2,3,
  5. José Natal Figueiroa2,4,
  6. João Guilherme B Alves4
  1. 1Universidade Federal da Paraíba—UFPB, Joao Pessoa, Paraíba, Brazil
  2. 2Clínica Esperança, Avenida Esperança 780, Manaíra, João Pessoa, Paraíba, Brazil
  3. 3Centro Universitário de João Pessoa—UNIPÊ, Joao Pessoa, Paraíba, Brazil
  4. 4Instituto de Medicina Integral Prof. Fernando Figueira—IMIP, Recife, Brazil
  1. Correspondence to Dr João Guilherme B Alves, Instituto de Medicina Integral Prof. Fernando Figueira—IMIP, Rua Antenor Navarro, 301, Recife 52050080, Brazil; joaoguilherme{at}imip.org.br

Abstract

Background Obstructive sleep apnoea syndrome (OSAS) is associated with cardiovascular disease, especially in patients with high blood pressure. Continuous positive airway pressure (CPAP) seems to contribute to blood pressure control in patients with OSAS, mainly those with uncontrolled hypertension. However, the effect of CPAP on controlled hypertensive patients with OSAS is not known.

Objective To evaluate the effects of CPAP on blood pressure of controlled hypertensive patients with OSAS.

Design Prospective cohort study.

Patients 36 recently diagnosed patients with OSAS and hypertension controlled with oral antihypertensive medication.

Methods CPAP was performed for 5 days. Systolic and diastolic blood pressure were recorded at baseline and 5 days later using 24 h ambulatory blood pressure measurement.

Results Mean (SD) 24 h systolic blood pressure was reduced from 128.9 (3.4) to 126.5 (3.5), p<0.001 and mean (SD) 24 h diastolic blood pressure was reduced from 86.9 (3.3) to 84.8 (3.3), p<0.001. A reduction in the proportion of ‘non-dippers’ in the participants was registered (from 40.6% at baseline to 18.2%).

Conclusions A short course of CPAP may reduce systolic and diastolic blood pressure in patients with OSAS and controlled hypertension.

Trial registration number RBR – 386qsg; Brazilian Clinical Trials Registry (REBEC).

  • SLEEP MEDICINE

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