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Association of HLA-DQB1 polymorphisms with rheumatoid arthritis: a meta-analysis
  1. Jun Wu1,2,
  2. Jun Li1,2,
  3. Si Li1,2,
  4. Tian-Ping Zhang1,2,
  5. Lian-Ju Li1,2,
  6. Tian-Tian Lv1,2,
  7. Hai-Feng Pan1,2,
  8. Dong-Qing Ye1,2
  1. 1 Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China
  2. 2 The Key Laboratory of Major Autoimmune Disease, Anhui Province, Anhui Medical University, Hefei, China
  1. Correspondence to Professor Hai-Feng Pan and Professor Dong-Qing Ye, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China; panhaifeng{at}ahmu.edu.cn, ydqahmu{at}gmail.com

Abstract

Aim Studies investigating the association between HLA-DQB1 alleles and rheumatoid arthritis (RA) have reported conflicting results. The purpose of this study was to evaluate whether DQB1 alleles confer susceptibility to RA.

Design A comprehensive literature search up to May 2016 was conducted to identify case-control studies on the association of HLA-DQB1 alleles with RA. Pooled ORs with 95% CIs were used to assess the strength of association.

Setting The literature indicates that HLA-DQB1 is associated with susceptibility to RA.

Main outcome measures Frequencies of HLA-DQB1 alleles and phenotype in RA patients and healthy controls.

Results Fifteen studies with 1250 cases and 1621 controls were included in this meta-analysis. DQB1 alleles were associated with RA susceptibility. The frequencies of DQB1*06 were lower in RA (p-value for comparability=0.007, OR 0.726,95% CI 0.576 to 0.916; p=0.004, OR 0.611,95% CI 0.438 to 0.852). The frequencies of DQB1*02 were lower in RA (p=0.044, OR 0.731,95% CI 0.597 to 0.895). A higher frequency of DQB1*04 was observed in RA (p=0.023, OR 1.604,95% CI 1.067 to 2.410).

Conclusions This meta-analysis demonstrates that DQB1*02 and DQB1*06 may be negatively associated with RA. Conversely, DQB1*04 may confer susceptibility to RA.

  • HLA-DQB
  • meta-analysis
  • polymorphisms
  • rheumatoid arthritis
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Footnotes

  • Acknowledgements This work was supported by grants from the National Natural Science Foundation of China (81473058, 81271759).

  • Contributors JW and JL: literature search, manuscript preparation, statistical analysis. SL, TPZ, LJL and TTL: manuscript preparation. HFP and DQY: manuscript revision, final language editing.

  • Funding This paper was supported by grants from the National Natural Science Foundation of China (grant nos: 81473058 and 81271759).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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