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Diabetes insipidus induced by suspected eosinophilic granulomatous with polyangiitis
  1. Yinghui Xie,
  2. Hui Shao,
  3. Chenlin Dai,
  4. Zhongshu Ma
  1. Endocrinology and Metabolism Department, General Hospital of Tianjin Medical University, Tianjin, China
  1. Correspondence to Dr C Dai, Endocrinology and Metabolism Department, General Hospital of Tianjin Medical University, AnShan road 154#, Heping District, Tianjin, PR China; daiandzhang{at}sina.com

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A 54-year-old man with a history of allergic rhinitis, chronic productive cough and shortness of breath presented with symptoms of ophthalmalgia, polydipsia, polyuria, ≥8 L daily urine output and 5 kg weight loss within 2 months. Physical examination revealed a haemorrhage under the sclera on the temporal side of the left eye (figure 1). The results of the fluid deprivation–vasopressin test showed central diabetes insipidus. Laboratory investigations showed circulating eosinophilia: 560×106/L (normal 50–300×106/L ), 5% (normal 0.5–5%); plasma antineutrophil cytoplasm antibodies (ANCA) …

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