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Clinicopathological and prognostic significance of survivin expression in renal cancer patients: a meta-analysis
  1. Chengquan Ma1,
  2. Bingxin Lu2,
  3. Erlin Sun3
  1. 1Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China
  2. 2Department of Urology, Tianjin Nankai hospital, Tianjin, China
  3. 3Tianjin institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China
  1. Correspondence to Dr Erlin Sun, Tianjin institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China; mchengquan{at}yahoo.com

Abstract

Background Survivin has been reported to play a role in the diagnosis and prognosis of renal cell carcinoma (RCC); however, published data on this subject are conflicting.

Aim To conduct a meta-analysis to evaluate the impact of survivin as a prognostic marker and its association with clinicopathological variables in patients with RCC.

Method Comprehensive searches of electronic databases (PubMed, ISI Web of Knowledge Embase, Google Scholar Web and the Cochrane Library) were updated to June 2016 to retrieve eligible studies. The association strength was measured with relative risks (RRs) and pooled HRs with 95% CIs, which were extracted and pooled to determine the association between survivin expression and patient survival and clinicopathological features.

Results Ten studies with 1063 cases of RCC were included. Positive survivin expression in RCC was associated with the TNM stage (pooled RR 1.49; 95% CI 1.07 to 2.07) or Fuhrman grade (pooled RR 1.63; 95% CI 1.15 to 2.32) in patients. The correlation between survivin expression and gender was not significant (pooled RR 0.97; 95% CI 0.83 to 1.15). In addition, a considerable association was found between survivin expression and overall survival for patients with RCC (pooled HR 1.94; 95% CI 1.24 to 3.05 (multivariate model) and 5.41; 95% CI 4.08 to 7.17 (univariate model)).

Conclusions Our results indicate that survivin is of prognostic significance in patients with RCC.

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