Article Text

PDF
Comparison of relationship between histopathological, serological and biochemical parameters in patients with chronic hepatitis B infection
  1. Husrev Diktas1,
  2. Zehra Karacaer2,
  3. I Ilker Özturk3,
  4. Huseyin Cicek2
  1. 1Department of Infectious Diseases and Clinical Microbiology, Tatvan Military Hospital, Bitlis, Turkey
  2. 2Department of Infectious Diseases and Clinical Microbiology, Etimesgut Military Hospital, Ankara, Turkey
  3. 3Department of Infectious Diseases and Clinical Microbiology, Beytepe Military Hospital, Ankara, Turkey
  1. Correspondence to Dr Husrev Diktas, Department of Infectious Diseases and Clinical Microbiology, 3 Tatvan Military Hospital, 4668 Tatvan-Bitlis 34688, Turkey; hd3207{at}gmail.com

Abstract

Objective To demonstrate the relationship between liver histology, alanine aminotransferase (ALT)/aspartate aminotransferase (AST) and hepatitis B virus (HBV) DNA levels based on hepatitis B e antigen (HBeAg) seropositivity status in naive patients with chronic hepatitis B (CHB).

Materials and method Naive patients with CHB admitted to our hospital between January 2012 and April 2014 were evaluated retrospectively. The patients were allocated into one of two groups based on HBeAg-seropositivity status.

Results Two hundred and fourteen patients were enrolled in the study. Of these 214 patients, 103 (48.1%) were HBeAg-positive and 111 (51.9%) were HBeAg-negative. In the HBeAg-positive group, positive correlations were found between histologic activity index (HAI) scores and ALT (t=3.3, r=0.31, p=0.001), AST (t=2.8, r=0.27, p=0.005) and HBV DNA load (t=2.5, r=0.24, p=0.014). Additionally, in this group, fibrosis scores had positive correlations with ALT (t=3.3, r=0.32, p=0.001) and AST (t=2.7, r=0.26, p=0.008). In the HBeAg-negative group, positive correlations were found between HAI scores and ALT (t=3, r=0. 28, p=0.003), AST (t=3, r=0. 28, p=0.003) and HBV DNA (t=5.3, r=0. 45, p=0). In this same group, fibrosis scores had a positive correlation with HBV DNA (t=2.2, r=0. 21, p=0.024). Multivariate logistic regression analysis showed a positive relationship between fibrosis and ALT in the HBeAg-positive group and a positive relationship between fibrosis and HBV DNA load in the HBeAg-negative group.

Conclusions This study showed that HBV DNA load is an independent predictive factor for evaluating HAI and fibrosis in the HBeAg-negative group. Also, ALT is an independent predictive factor for evaluating fibrosis in the HBeAg-positive group.

  • Hepatitis B
  • correlation
  • ALT
  • AST
  • HBV DNA

Statistics from Altmetric.com

Footnotes

  • This manuscript was presented as a poster at the 24th ECCMID Congress, Copenhagen, Denmark

  • Contributors Writing of the manuscript: HD; statistical analysis: ZK; data analysis: IIÖ and HC.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Ethics committee of Etimesgut Military Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.