Article Text

PDF
The usefulness of cardiopulmonary exercise testing in assessment of patients with suspected coronary artery disease
  1. Reza Mazaheri1,2,
  2. Farshad Shakerian3,
  3. Ali Vasheghani-Farahani4,
  4. Farzin Halabchi1,2,
  5. Maryam Mirshahi1,5,
  6. Mohammad Ali Mansournia6
  1. 1Sports Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2Faculty of Medicine, Department of Sports and Exercise Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6Department of Epidemiology & Biostatistics, Tehran University of Medical Sciences, Tehran, Iran
  1. Correspondence to Dr Maryam Mirshahi, Sina Hospital, Imam Khomeini Ave., Hassan Abad Sq., PO Box 1136746911, Tehran, Iran; m.mirshahi2000{at}yahoo.com

Abstract

Objective The aim of this study is to assess different parameters of cardiopulmonary exercise testing that can predict the development of myocardial ischaemia in patients with suspected coronary artery disease (CAD) and to identify the parameters which have more correlation with myocardial ischaemia.

Study design Cross-sectional study.

Methods In this study, a total of 31 men (mean age 57.23±11.09 years) with suggestive symptoms of CAD underwent an exercise stress test with breath-by-breath gas exchange analysis, followed by coronary angiography as the gold standard for diagnosing CAD.

Results The ventilation versus CO2 output (VE/VCO2) peak was significantly different between patients with negative and positive angiography results. Receiver operator characteristic analysis showed an area under the curve of 0.73 for VE/VCO2 peak with diagnostic threshold equal to 35 (95% CI 0.54 to 0.9; p=0.05). Exercise stress testing had sensitivity and specificity of 75% and 40%, respectively.

Conclusions A change in ventilatory efficiency assessed using the VE/VCO2 peak has the predictive ability to identify exercise-induced myocardial ischaemia. The present study has provided additional evidence of the potential clinical value of cardiopulmonary exercise testing in the diagnosis of CAD.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.