Article Text

PDF
Understanding the role of mitochondria in the pathogenesis of chronic pain
  1. Bing-dong Sui1,2,
  2. Tian-qi Xu2,
  3. Jie-wei Liu2,
  4. Wei Wei2,
  5. Chen-xi Zheng2,
  6. Bao-lin Guo2,
  7. Ya-yun Wang1,2,
  8. Yan-ling Yang3
  1. 1Department of Human Anatomy, Histology and Embryology, K.K. Leung Brain Research Centre, School of Basic Medicine, The Fourth Military Medical University, Xi'an, China
  2. 2School of Stomatology, The Fourth Military Medical University, Xi'an, China
  3. 3Department of Hepatobiliary Surgery, Xi-Jing Hospital, The Fourth Military Medical University, Xi'an, China
  1. Correspondence to Dr Ya-yun Wang, Changle West Road 169, Xi'an 710032, China; wangyy{at}fmmu.edu.cn, or Dr Yan-ling Yang, Department of Hepatobiliary Surgery, Xi-Jing Hospital, The Fourth Military Medical University, Xi'an 710032, China; yangyanl{at}fmmu.edu.cn

Abstract

Chronic pain is a major public health problem. Mitochondria play important roles in a myriad of cellular processes and mitochondrial dysfunction has been implicated in multiple neurological disorders. This review aims to provide an insight into advances in understanding of the role of mitochondrial dysfunction in the pathogenesis of chronic pain. The results show that the five major mitochondrial functions (the mitochondrial energy generating system, reactive oxygen species generation, mitochondrial permeability transition pore, apoptotic pathways and intracellular calcium mobilisation) may play critical roles in neuropathic and inflammatory pain. Therefore, protecting mitochondrial function would be a promising strategy to alleviate or prevent chronic pain states. Related chronic inflammatory and neuropathic pain models, as well as the spectral characteristics of current fluorescent probes to detect mitochondria in pain studies, are also discussed.

  • Chemical Pathology
  • Neurophysiology

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.