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Neurocognitive sequelae following hippocampal and callosal lesions associated with cerebral malaria in an immune-naive adult
  1. Etienne Laverse1,
  2. Lina Nashef1,
  3. Satsuki Brown2
  1. 1Department of Neurology, King's College Hospital, London, UK
  2. 2Department of Neuroradiology, King's College Hospital, London, UK
  1. Correspondence to Dr Etienne Laverse, Department of Neurology, King's College Hospital, London, UK; etienne.laverse{at}imperial.ac.uk

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Introduction

Cerebral malaria, a diffuse encephalopathy caused by Plasmodium falciparum, is associated with long-term neurocognitive impairments.1 ,2 P falciparum remains the most common parasitic infection of the central nervous system with characteristic clinico-radiological manifestations. Over two billion people are affected by malaria each year, with mortality of over one million.1 It has been estimated that between 5% and 26% of affected children have cognitive impairment.1 ,2 The prevalence of cognitive impairment in adults is not known, primarily due to a lack of long-term follow-up studies.

Case history

We report a case of a 36-year-old immune-naive Caucasian female who sustained a brain injury with neurocognitive sequelae, after a severe bout of falciparum malaria.

On admission, she was unconscious, febrile, …

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